Deep Inspiration Breath Hold in Left-Sided Breast Radiotherapy: A Balance Between Side Effects and Costs
Authors' conclusion
Despite time investments, DIBH is cost-effective in the Belgian population.
Study context
- Population
- Patients with left-sided breast cancer receiving radiotherapy (Belgian population)plans with both techniques
- Participants
- 100 patients
- Comparison
- Deep inspiration breath hold (DIBH) vs free breathing (FB)
- Outcome
- Cost-effectiveness of DIBH vs FB (incremental cost-effectiveness ratio per QALY)
- Follow-up
- 20 years
Methodological detailsmicrosimulation and discrete event simulation modelling study, dosimetric planning comparison, state-transition microsimulation model (SCORE2), time-driven activity-based costing, provider perspective, willingness-to-pay threshold €40,000
- Microsimulation and discrete event simulation modelling study
- Dosimetric planning comparison
- State-transition microsimulation model (SCORE2)
- Time-driven activity-based costing
- Provider perspective
- Willingness-to-pay threshold €40,000
Main finding
As reported in the abstract
Cost-effectiveness (ICER)
Incremental cost
617 € per left-sided breast cancer patient (95% CI €615-€619)
DIBH
Incremental quality-adjusted life-years (QALYs)
0.04 QALYs per patient
95% CI 0.05–0.05
DIBH
- ICER (willingness-to-pay threshold €40,000)
- €14,023 per QALY
Further findings
| Outcome | Estimate |
|---|---|
| Total CV events · 20 yearsBase case scenario | absolute risk reduction 1.72% (95% CI 1.67%–1.76%) |
| Fatal CV events · 20 yearsBase case scenario | absolute risk reduction 0.69% (95% CI 0.67%–0.72%) |
| Maximum achievable throughput (reduction with DIBH)DIBH increased treatment times | reduction 12.48% (95% CI 12.36%–12.75%) |
Original publication
Deep Inspiration Breath Hold in Left-Sided Breast Radiotherapy: A Balance Between Side Effects and Costs. JACC CardioOncol. Published 2 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →