Cardiovascular Disease in Pregnancy: Clinical Outcomes and Cost-Associated Burdens From a National Cohort at Delivery
Main finding · MACE, obstetric complications, neonatal complications, maternal mortalityResult — go to the resultAdjusted odds ratio 9.28 95% CI 6.35–13.56Authors' conclusion
CVD in pregnancy is associated with higher rates of adverse outcomes.
Study context
- Population
- Pregnant people admitted for delivery hospitalization, US National Inpatient Sample 2010–2019
- Participants
- 33,639,831 birth hospitalizations
- Exposure
- Pregnant people with cardiovascular disease (CVD) vs without CVD at delivery
- CVDn = 132,532
- Outcome
- Adverse maternal cardiac (MACE), maternal obstetric and neonatal outcomes, and costs
- Follow-up
- Delivery hospitalization
Methodological detailsNational Inpatient Sample 2010-2019
- National Inpatient Sample 2010-2019
Main finding
As reported in the abstract
MACE, obstetric complications, neonatal complications, maternal mortality
Adjusted odds ratio
9.28
95% CI 6.35–13.56
Events by group
CVD
132,532
events
CVDvs No CVD
aOR 9.28 (95% CI 6.35–13.56)
Observational data: associations, not effects.
Further findings
Factors associated with major adverse cardiovascular events (MACE)
| aOR (95% CI) | ||
|---|---|---|
| Cardiomyopathy | 49.9 (45.2–55.1) | |
| Congenital heart disease | 13.8 (12.0–15.9) | |
| Black race | 1.04 (1.00–1.08) | |
| Low income | 1.06 (1.02–1.11) | |
| Governmental insurance | 1.03 (1.00–1.07) | |
| 0.050.21520Adjusted odds ratio (log scale) |
Original publication
Cardiovascular Disease in Pregnancy: Clinical Outcomes and Cost-Associated Burdens From a National Cohort at Delivery. JACC Adv. Published 2 July 2024. doi:10.
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