Acute cardiac care & resuscitation
Baseline measurements of cellular respiration affect the response to thiamine treatment in post-arrest patients
Primary result · Change in lactateResult — go to the resultGeometric mean ratio 0.83 95% CI 0.64–1.09Authors' conclusion
Thiamine supplementation was associated with reduced lactate in patients with preserved mitochondrial functional reserve. Baseline mitochondrial respiration may serve as a biomarker to identify critically ill patients most likely to benefit from metabolic resuscitation therapies.
Study context
- Population
- Cardiac arrest patients with baseline mitochondrial oxygen consumption rate measurements in peripheral blood mononuclear cellspatients with baseline OCR measurements included in the analysis
- Participants
- 74 patients
- Comparison
- Thiamine compared to placebo
- Thiaminen = 40
- Placebon = 34
- Primary endpoint
- change in lactate
- Follow-up
- 24 h
Primary result
As reported in the abstract
Geometric mean ratio
0.83
95% CI 0.64–1.09
P = 0.19
Thiaminevs placebo
GMR 0.83 (95% CI 0.64–1.09); P = 0.19
Further findings
| Outcome | GMR (95% CI) | P value | |
|---|---|---|---|
| Lactate among patients with maximal respiration above the median (subgroup) · 24 h | 0.61 (0.44–0.83) | P = 0.003 | |
| Lactate among patients with spare respiration above the median (subgroup) · 24 h | 0.53 (0.38–0.75) | P < 0.001 | |
| 0.20.5125Geometric mean ratio (log scale) |
Original publication
Baseline measurements of cellular respiration affect the response to thiamine treatment in post-arrest patients. Resuscitation. Published 25 February 2026. doi:10.
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