Acute cardiac care & resuscitationSecondary analysis
Bayesian Reanalyses of the Trials TOMAHAWK and COACT
- Post hoc Bayesian reanalysis of the TOMAHAWK and COACT randomised trials
- multicentre
- Bayesian logistic regression
- flat, neutral, optimistic and pessimistic priors
Authors' conclusion
Bayesian reanalyses showed a very high probability of increased 30-day mortality risk with immediate compared with delayed/selective coronary angiography in the TOMAHAWK trial and combined trial cohort.
Study context
- Population
- Patients successfully resuscitated after OHCA without ST-segment elevation on ECG2 RCTs
- Comparison
- Immediate vs delayed/selective coronary angiography
- Primary endpoint
- All-cause mortality
- Follow-up
- 30 days
Primary result
As reported in the abstract
30-day all-cause mortality (Bayesian logistic regression)
TOMAHAWK: posterior probability of increased mortality with immediate coronary angiography, across all priors
90% and 97%
COACT: ORs for 30-day mortality
0.98 to 1.11
Combined trials: probability of increased mortality with immediate coronary angiography, across all priors
83% and 95%
Original publication
Bayesian Reanalyses of the Trials TOMAHAWK and COACT. JACC Cardiovasc Interv. Published 23 December 2024. doi:10.1016/j.jcin.2024.09.071
Summarised from the published abstract; every number is checked against it