Arrhythmias & electrophysiology
Best ablation strategy in patients with premature ventricular contractions with multiple morphology: a single-centre experience
Authors' conclusion
In this observational series, ablation of all PVC morphologies was associated with significantly lower PVC burden and improvement of LVEF at long-term follow-up, compared with ablation of the dominant morphology only.
Study context
- Population
- Patients with reduced left ventricular ejection fraction (LVEF) and ≥2 Premature ventricular complex (PVC) morphologies with high burden (>10%/day) undergoing first ablation
- Participants
- 171 consecutive patients
- Exposure
- Ablation of all PVC morphologies vs dominant PVC only
- All PVC morphologiesn = 19
- Dominant PVC onlyn = 152reference
- Outcome
- PVC burden after repeat procedure (all morphologies ablated)
- Follow-up
- 5 years after repeat procedure
Methodological detailssingle-centre, consecutive patients
- Single-centre
- Consecutive patients
Main finding
As reported in the abstract
| Group | Value | PVC burden |
|---|---|---|
| Successful | 91% | 3.8 ± 1.1% |
| Failed | 15.4 ± 4.3% |
Value
Successful91%
Failed— not stated in the abstract
PVC burden
Successful3.8 ± 1.1%
Failed15.4 ± 4.3%
- Successful vs Failed: P < 0.001 — PVC burden
- PVC burden <5% after repeat procedure in 78 patients
- 71 (91%)
Observational data: associations, not effects.
Further findings
LVEF change after initial procedure, by PVC burden
| MD (%) | P value | |
|---|---|---|
| Low PVC burdenLVEF 37.5% to 41.6% | 3.39 ± 2.9 | P < 0.001 |
| High PVC burdenLVEF reduced 39.8% to 34.5% | 6.45 ± 4.7 | P < 0.001 |
| Outcome | MD (%) | P value |
|---|---|---|
| LVEF change after successful repeat ablation · 1 year after repeat procedureLVEF 36.2% to 41.7% | 5.5 ± 4.3 | P < 0.001 |
High PVC burden after initial procedure · 2 years
- High PVC burden detected
- 89 (52%)
- Repeat procedure performed (all morphologies ablated)
- 78 of 89
Original publication
Best ablation strategy in patients with premature ventricular contractions with multiple morphology: a single-centre experience. Europace. Published 21 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →