Arrhythmias & electrophysiology
Focal Pulsed Field Ablation for Premature Ventricular Contractions: A Multicenter Experience
Authors' conclusion
PVC ablation using a focal PFA is feasible, effective, and safe, with promising acute and long-term results in several ventricular locations. Irritative firing is frequently observed.
Study context
- Population
- Patients referred for premature ventricular contraction (PVC) ablation, regardless of structural heart disease, PVC morphology or previous ablation attempts
- Participants
- 20 patients
Methodological detailsmulticentre, 2 centres
- Multicentre
- 2 centres
Main finding
As reported in the abstract
Acute procedural success
Acute procedural success (17 of 20 patients)
85%
95% CI 0.70–1
Observational data: associations, not effects.
Further findings
Mean peak-to-peak bipolar electrogram voltage, before vs after ablation
reduction 76% · P = 0.008
Chronic success · median follow-up 120 days
- Late success (>80% clinical PVC burden suppression) after procedural failure
- 2
- Late PVC recurrence after acute success
- 2 of 17
Procedural characteristics
- General anesthesia
- 11 (55%)
- Deep sedation
- 6 (30%)
- Light sedation
- 3 (15%)
- Median procedural time (minutes)
- 95.5
- Median fluoroscopy time (minutes)
- 6.55
- Median number of pulsed field ablation (PFA) applications
- 8
- Median contact force
- 10g
- Ventricular irritative firing after PFA
- 11 (55%)
Safety
Procedural complications
- Muscular contraction
- 1 (5%)
- Transient ST-segment depression
- 1
- Right bundle branch block induced (permanent in 1)
- 2
Original publication
Focal Pulsed Field Ablation for Premature Ventricular Contractions: A Multicenter Experience. Circ Arrhythm Electrophysiol. Published 5 September 2024. doi:10.
Summarised from the published abstract; every number is checked against it