Heart failure & cardiomyopathiesCohort study
Biatrial Myopathy in Heart Failure with Preserved Ejection Fraction
- Retrospective cohort study
- single-centre
- consecutive patients
Authors' conclusion
Biatrial myopathy identifies patients with more advanced HFpEF characterized by more severe pulmonary vascular disease, right HF, poorer cardiac reserve, and a greater risk for adverse outcomes.
Study context
- Population
- Patients with HFpEF defined by invasive exercise testing, Mayo Clinic, 2006–201894 with events
- Participants
- 476 patients
- Exposure
- Biatrial myopathy vs Isolated left atrial (LA) myopathy
- No atrial myopathyn = 125
- Isolated LA myopathyn = 147reference
- Biatrial myopathyn = 184
- Isolated right atrial (RA) myopathyn = 20
- Outcome
- Heart failure (HF) hospitalization or death
- Follow-up
- Median 2.9 (IQR 1.4-4.6) years
Main finding
As reported in the abstract
Hazard ratio
1.84
95% CI 1.16–2.92
P = 0.01
Biatrial myopathy vs Isolated LA myopathy
HR 1.84 (95% CI 1.16–2.92); P = 0.01
Observational data: associations, not effects.
Further findings
Clinical and haemodynamic characteristics
- Biatrial myopathy: more AF, poorer LV systolic and diastolic function, more severe pulmonary vascular disease, tricuspid regurgitation, ventricular interdependence, RV dysfunction, poorer cardiac output reserve with exercise
Original publication
Biatrial Myopathy in Heart Failure with Preserved Ejection Fraction. Eur J Heart Fail. Published 13 December 2023. doi:10.1002/ejhf.3104
Summarised from the published abstract; every number is checked against it