Heart failure & cardiomyopathies
Biomarkers of Right Ventricle (RV) Dysfunction in HFrEF Identified by Direct Tissue Proteomics: Extracellular Proteins Fibromodulin and Fibulin-5
Authors' conclusion
Our study proposes that circulating levels of FMOD and FBLN5 may serve as new biomarkers of RVD in patients with heart failure with reduced ejection fraction.
Study context
- Population
- Patients with heart failure with reduced ejection fraction; proteomic analysis in patients who underwent heart transplantationseparate cohort of patients with heart failure with reduced ejection fraction
- Participants
- 232 patients
- Exposure
- Association of the 2 proteins with RV function and long-term outcomes
- With right ventricular dysfunction (RVD)n = 10
- Without RVDn = 10
- Outcome
- Association of plasma FMOD and FBLN5 with RV function
Methodological detailsseparate cohort
- Separate cohort
Main finding
As reported in the abstract
- Plasma concentrations of both FMOD and FBLN5 were significantly associated with RV function regardless of the RV function assessment method
- Multivariable linear regression
Observational data: associations, not effects.
Further findings
Association of FMOD or FBLN5 with left ventricular dysfunction, cardiac index, body mass index, diabetes status, or kidney function
- No association
Association of plasma FMOD and FBLN5 with patient outcomes
- FMOD
- P = 0.005
- FBLN5
- P = 0.004
Area under the curve, addition of FBLN5 or FMOD to RV function assessment vs RV function alone · after 4 years of follow-up
- RV function + FBLN5
- 0.653
- RV function + FMOD
- 0.631
- RV function alone
- 0.570
- P <0.05 for both
Area under the curve, MAGGIC score, FBLN5, and FMOD vs MAGGIC score+RVD grade
- MAGGIC score, FBLN5, and FMOD
- 0.669
- MAGGIC score+RVD grade
- 0.572
- P =0.02
Prognosis, Kaplan-Meier analysis: elevation of both FMOD and FBLN5 vs elevation of either
- Patients with the elevation of both FMOD and FBLN5 (ie, FMOD >64 ng/mL and FMOD >27 ng/mL) had a worse prognosis than those with the elevation of either FBLN5 or FMOD
- P = 0.03
- Demonstrating the additive prognostic value of both proteins
Original publication
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