Heart failure & cardiomyopathies
Cardiopulmonary Exercise Testing as a Prognosis-Assessing Tool in Heart Failure with Preserved Ejection Fraction
Main finding · Composite of hospitalization for heart failure or cardiovascular deathResult — go to the resultHazard ratio 2.69 95% CI 1.00–7.21Authors' conclusion
In patients with heart failure with preserved ejection fraction, a VE/VCO2 slope > 34 predicts heart failure hospitalizations and cardiovascular death.
Study context
- Population
- Outpatients with newly diagnosed heart failure with preserved ejection fraction who underwent cardiopulmonary exercise testing (CPET), August 2016 to May 2019patients who underwent CPET
- Participants
- 99 outpatients
- Exposure
- VE/VCO2 slope > 34 vs VE/VCO2 slope ≤ 34
- VE/VCO2 slope > 34n = 59
- VE/VCO2 slope ≤ 34n = 40reference
- Outcome
- Composite of:
- Hospitalization for heart failure
- Cardiovascular death
- Follow-up
- Median 30 months
Main finding
As reported in the abstract
Hazard ratio
2.69
95% CI 1.00–7.21
P = 0.04
Events by group
VE/VCO2 slope > 34vs VE/VCO2 slope ≤ 34
hazard ratio 2.69 (95% CI 1.00–7.21); P = 0.04
Observational data: associations, not effects.
Further findings
Heart failure hospitalization or cardiovascular death as a terminal event (multivariate analysis)
- VE/VCO2 slope was independently associated with heart failure hospitalization or cardiovascular death as a terminal event
- Multivariate analysis
Baseline characteristics and CPET parameters
- Median follow-up
- 30 months [interquartile range, 24-38.5]
- Mean age
- 75.07 ± 7.31 years
- Women
- 49%
- NYHA class II
- 75%
- Median NTproBNP
- 511 pg/mL
- Mean peakVO2
- 15.09 ± 4.75
- Mean VE/VCO2
- 36.05 ± 6.60
- Threshold values: peakVO2 < 14 mL/min/kg and VE/VCO2 slope > 34
Events during follow-up
- All-cause hospitalizations
- 207
- Cardiovascular hospitalizations
- 126
- Heart failure hospitalizations
- 58
- Deaths
- 4
Original publication
Cardiopulmonary Exercise Testing as a Prognosis-Assessing Tool in Heart Failure with Preserved Ejection Fraction. ESC Heart Fail. Published 16 January 2025. doi:10.
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