Arrhythmias & electrophysiology
Bleeding, stroke, and mortality risk of patients with septic shock receiving anticoagulation for atrial fibrillation
Authors' conclusion
In patients with septic shock and AF, AC was not associated with a higher incidence of bleeding or lowering of in-hospital strokes but was associated with decreased mortality, potentially protecting against disseminated intravascular coagulopathy or other embolic phenomena.
Study context
- Population
- Hospitalised patients with septic shock and atrial fibrillation (AF) (subgroup: new-onset AF)
- Participants
- 604 patients
- Exposure
- Therapeutic anticoagulation vs no anticoagulation
- Outcome
- In-hospital stroke and significant bleeding
Methodological detailssingle-centre, propensity-score matched
- Single-centre
- Propensity-score matched
Main finding
As reported in the abstract
AC vs Without ACRelative risk (95% CI)
Bleeding, AF
1.33(0.81–2.17)
Bleeding, new-onset AF
1.60(0.72–3.54)
Observational data: associations, not effects.
Further findings
Mortality · AF · propensity score-matched cohorts
P = 0.01
Mortality · new-onset AF · propensity score-matched cohorts
P = 0.04
Safety
| Outcome | RR (95% CI) | |
|---|---|---|
| Bleeding (BARC 2 and 3a most common)ACvs Without ACAF | 1.33 (0.81–2.17) | |
| Bleeding (BARC 2 and 3a most common)ACvs Without ACNew-onset AF | 1.60 (0.72–3.54) | |
| 0.20.5125Relative risk (log scale) |
Original publication
Bleeding, stroke, and mortality risk of patients with septic shock receiving anticoagulation for atrial fibrillation. Heart Rhythm. Published 6 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →