Arrhythmias & electrophysiology
The outcomes of patients with septic shock treated with propafenone compared to amiodarone for supraventricular arrhythmias are related to end-systolic left atrial volume
Authors' conclusion
Patients with non-dilated LA who achieved rhythm control with propafenone in the setting of septic shock had better short-term and long-term outcomes than those treated with amiodarone, which seemed to be more effective in patients with LAVI ≥ 40 mL/m².
Study context
- Population
- Patients with new-onset supraventricular arrhythmia (SVA) in septic shock and LVEF ≥ 35%, by end-systolic left atrium (LA) volume (LAVI <40 vs ≥40 mL/m²)
- Comparison
- Propafenone vs amiodarone
- Primary endpoint
- Survival (subgroup outcomes)
- Follow-up
- ICU discharge, 1, 3, 6 and 12 months
Methodological detailssubgroup analysis by LA volume
- Subgroup analysis by LA volume
Primary result
As reported in the abstract
Mortality, by LAVI subgroup
Propafenone vs AmiodaroneHazard ratio (95% CI)P value
LAVI < 40 mL/m² (n = 133), 1 year, Cox regression
0.6(0.4–0.9)
P = 0.014LAVI ≥ 40 mL/m² (n = 37), 1 month
3.6(1.03–12.5)
P = 0.045LAVI ≥ 40 mL/m² (n = 37), 1 year
1.9(0.8–4.4)
P = 0.138Further findings
Rhythm control, LAVI < 40 mL/m² (subgroup)
- Propafenone cardioverted earlier
- P = 0.009
- Propafenone: fewer recurrences
- P = 0.001
Rhythm control, dilated LA (subgroup)
- Earlier rhythm control with amiodarone
- P = 0.05
- Similar rates of recurrences
- P = 0.5
Original publication
The outcomes of patients with septic shock treated with propafenone compared to amiodarone for supraventricular arrhythmias are related to end-systolic left atrial volume. Eur Heart J Acute Cardiovasc Care. Published 19 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →