Blood Pressure Effect of Traffic-Related Air Pollution : A Crossover Trial of In-Vehicle Filtration
Authors' conclusion
Filtration of TRAP may mitigate its adverse effects on blood pressure rapidly and at 24 hours.
Study context
- Population
- Normotensive persons aged 22 to 45 years on scripted in-vehicle commutes through traffic, Seattle, 2014 to 201613 with complete data
- Participants
- 16 persons
- Comparison
- Unfiltered vs high-efficiency particulate air (HEPA)-filtered in-vehicle air during on-road commutes
- Primary endpoint
- BP and retinal vasculature (CRAE)
Methodological detailsparticipant-blinded, Imprecise estimates due to small sample size; seasonal imbalance by exposure order
- Participant-blinded
- Imprecise estimates due to small sample size; seasonal imbalance by exposure order
Primary result
As reported in the abstract
Adjusted BP (adjusted for predrive levels, order, carryover) · 1 hour
Unfiltered vs FilteredDifference, mm Hg (95% CI)
DBP
4.7(0.9–8.4)
SBP
4.5(−1.2 to 10.2)
Further findings
| Outcome | Difference (mm Hg) (CI) | |
|---|---|---|
| Adjusted BP · up to 24 hoursUnfilteredvs FilteredDBP | 3.8 (0.02–7.5) | |
| Adjusted BP · up to 24 hoursUnfilteredvs FilteredSBP | 1.1 (−4.6 to 6.8) | |
| −50510Difference, mm Hg (linear scale) |
| Outcome | Difference (μm) (CI) | |
|---|---|---|
| Adjusted mean CRAEWider unfiltered | 2.7 (−1.5 to 6.8) | |
| −50510Difference, μm (linear scale) |
Particle count
- Filtration reduced particle count
- 86%
Original publication
Blood Pressure Effect of Traffic-Related Air Pollution : A Crossover Trial of In-Vehicle Filtration. Ann Intern Med. Published 28 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →