HypertensionCohort study
Blood pressure, proteomic vascular ageing, and incident cardiovascular disease
- Cohort study
Authors' conclusion
High blood pressure is associated with accelerated proteomic vascular ageing, which potentially mediates its link to cardiovascular events.
Study context
- Population
- UK Biobank participants
- Participants
- 45,387 participants
- Exposure
- BP categories vs normotension
- Outcome
- Proteomic vascular age gap (signature from 21 heart- and artery-enriched proteins, LightGBM model)
Main finding
As reported in the abstract
Vascular age gap vs normotensive
| Group | Value | P |
|---|---|---|
| High-normal BP | 0.122 ± 0.048 years | P = 0.011 |
| Grade 1 hypertension | 0.266 ± 0.049 years | P < 0.001 |
| Grade 2 hypertension | 0.494 ± 0.071 years | P < 0.001 |
Observational data: associations, not effects.
Further findings
Mediation of Grade 2 hypertension–CV events association by vascular age gap
- Proportion possibly mediated
- 3.73-10.59%
- No mediation for PAD in Grade 2 hypertension
- TNFRSF11B and CRLF1 consistently contributed to mediation across BP categories and outcomes
Original publication
Blood pressure, proteomic vascular ageing, and incident cardiovascular disease. Eur J Prev Cardiol. Published 5 December 2025. doi:10.1093/eurjpc/zwaf757
Summarised from the published abstract; every number is checked against it