Occurrence and Patient Characteristics of Aldosterone Dysregulation in Routine Clinical Care: A Population-Based Study
Authors' conclusion
In this first nationwide study of AD, detected AD was 4 times more prevalent in adults with hypertension compared to the general population. One in 4 hypertensive adults tested met the AD threshold of ARR ≥27.7 pmol/mIU and they had higher intensity of antihypertensive therapy.
Study context
- Population
- Danish adults, nationwide health registries with complete laboratory results, 2017–202418,650 aldosterone-renin ratio (ARR) tested
- Participants
- 5.42 million adults
- Exposure
- Hypertensive adults vs general population
- Outcome
- Annual proportion of ARR testing and AD occurrence (ARR ≥27.7 pmol/mIU)
Methodological detailsnationwide, health registries
- Nationwide
- Health registries
Main finding
As reported in the abstract
AD prevalence per 100,000 · 2023
Observational data: associations, not effects.
Further findings
Aldosterone dysregulation (AD) among tested hypertensive adults, by ARR threshold
- ARR ≥27.7 pmol/mIU
- 25.0%
- ARR ≥138.7 pmol/mIU
- 4.5%
- ARR ≥225.8 pmol/mIU
- 1.8%
Hypertension duration, hypertensive adults with vs without AD
- Longer hypertension duration with AD (years)
- 7.1 vs 5.2
- More concurrent antihypertensive drugs with AD
Original publication
Occurrence and Patient Characteristics of Aldosterone Dysregulation in Routine Clinical Care: A Population-Based Study. JACC Adv. Published 4 December 2025. doi:10.
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