Blood Transfusion in Patients With Acute Myocardial Infarction, Anemia, and Heart Failure: Lessons From MINT
Authors' conclusion
A liberal transfusion strategy is safe for patients with MI and anemia, including those with baseline HF. Restrictive transfusion tended to result in worse outcomes, particularly in patients with baseline HF.
Study context
- Population
- Patients with myocardial infarction (MI) and anemia (hemoglobin <10 g/dL), with and without baseline heart failure (HF)randomized patients with MI and anemia
- Participants
- 3,504 patients
- Comparison
- We compared the effects of transfusion strategy on outcomes among patients with and without baseline HF
- Baseline HFn = 1,871
- Without baseline HFn = 1,633
- Primary endpoint
- death or HF
- Follow-up
- 30 days
Methodological detailsrandomized
- Randomized
Primary result
As reported in the abstract
restrictive vs liberalRate ratio (95% CI)
Patients with baseline HF
1.20(0.99–1.45)
Patients without baseline HF
0.94(0.70–1.26)
Secondary outcomes
| Outcome | Rate ratio (95% CI) | |
|---|---|---|
| HFRestrictivevs liberal | 0.51 (0.29–0.92) | |
| 0.20.5125Rate ratio (log scale) |
- HF: patients without baseline HF; lower with restrictive transfusion
- HF: P interaction =0.02
Death or recurrent MI; death (secondary outcomes)
- More frequent among those with baseline HF
- Restrictive transfusion resulted in numerically higher rates of death or MI and death in patients with than in those without baseline HF
HF
- Rates of HF similar between restrictive and liberal transfusion in patients with baseline HF
Original publication
Blood Transfusion in Patients With Acute Myocardial Infarction, Anemia, and Heart Failure: Lessons From MINT. Circ Heart Fail. Published 26 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →