Prevention & lipidsResearch article
Body mass index and body composition in relation to 14 cardiovascular conditions in UK Biobank: a Mendelian randomization study
- Mendelian randomization study
Authors' conclusion
This study provides evidence that higher BMI and particularly fat mass index are associated with increased risk of aortic valve stenosis and most other cardiovascular conditions.
Study context
- Population
- UK Biobank participantsUK Biobank
- Participants
- 367,703 participants
- Comparison
- Genetically predicted body mass index (BMI), fat mass index and fat-free mass index vs CV conditions
- Outcome
- Associations of BMI with 13 cardiovascular diseases (CVDs) and arterial hypertension
Main finding
As reported in the abstract
Genetically predicted BMI and CV outcomes (per 1 kg/m² increase in BMI)
PE: OR 1.06 (95% CI 1.02-1.11)
P = 2.6 × 10-3
AS: OR 1.13 (95% CI 1.05-1.21)
P = 1.2 × 10-3
Further findings
Genetically predicted fat mass index
- Suggestive positive associations with 9 outcomes
- P < 0.05
- AS: OR per 1 kg/m² increase in fat mass index 1.46 (95% CI 1.13-1.88)
- P = 3.9 × 10-3
Fat-free mass index
- Suggestive inverse associations with AF, ischaemic stroke and AAA
Original publication
Body mass index and body composition in relation to 14 cardiovascular conditions in UK Biobank: a Mendelian randomization study. Eur Heart J. Published 13 June 2019. doi:10.1093/eurheartj/ehz388
Summarised from the published abstract; every number is checked against it