Body mass index, waist circumference, and mortality in subjects older than 80 years: a Mendelian randomization study
Authors' conclusion
Among the oldest-old, opposite causal associations of BMI and WC with mortality were observed, and a body figure with higher BMI and lower WC could substantially decrease the mortality risk.
Study context
- Population
- Community-based oldest-old (aged ≥80 years; mean age 90.6 years) in China, Chinese Longitudinal Healthy Longevity Survey (CLHLS) 1998–20183,766 deaths
- Participants
- 5,306 participants
- Exposure
- Genetically predicted body mass index (BMI) and waist circumference (WC) vs mortality
- Outcome
- All-cause mortality, cardiovascular disease (CVD) mortality and non-CVD mortality
Methodological detailsone-sample linear and non-linear Mendelian randomization (MR), community-based cohort (CLHLS), 24 337 person-years of follow-up, Genetic risk scores from 58 BMI single-nucleotide polymorphisms (SNPs) and 49 WC SNPs
- One-sample linear and non-linear MR
- Community-based cohort (CLHLS)
- 24 337 person-years of follow-up
- Genetic risk scores from 58 BMI SNPs and 49 WC SNPs
Main finding
As reported in the abstract
All-cause, CVD and non-CVD mortality (linear MR)
Hazard ratio (95% CI)
BMIgenetically predicted BMI, per 1 kg/m²; all-cause mortality
0.955(0.928–0.983)
WCper 5 cm increase; all-cause mortality
1.108(1.036–1.185)
WCCVD mortality
1.193(1.064–1.337)
WCnon-CVD mortality
1.110(1.016–1.212)
Each row per its own increment, as printed
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Mortality (observational analyses)BMI (per 1-kg/m² increment) | 0.963 (0.955–0.971) | |
| Mortality (observational analyses)WC (per 5 cm increase) | 0.971 (0.950–0.993) | |
| 0.512Hazard ratio (log scale) |
Original publication
Body mass index, waist circumference, and mortality in subjects older than 80 years: a Mendelian randomization study. Eur Heart J. Published 16 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →