Acute cardiac care & resuscitationCohort study
Cangrelor During Percutaneous Coronary Intervention in Patients With Cardiogenic Shock or Cardiac Arrest
- Retrospective registry-based cohort study
- propensity-score matched
- SCAAR registry
Authors' conclusion
For patients with cardiogenic shock, administration of cangrelor during PCI was associated with a lower risk for both MACE and all-cause mortality. For patients with cardiac arrest, no such benefit was observed, and a higher risk for major bleeding was found.
Study context
- Population
- Patients undergoing percutaneous coronary intervention (PCI) (2016–2022) for MI with cardiogenic shock or cardiac arrest, Swedish registry (SCAAR)
- Participants
- 3,014 patients
- Exposure
- Cangrelor vs no cangrelor during PCI
- Cangrelorn = 1,011
- No cangrelorn = 2,003reference
- Outcome
- Major adverse cardiovascular events (MACE), in-hospital major bleeding and all-cause mortality
- Follow-up
- 30 days (MACE, mortality)
Main finding
As reported in the abstract
MACE and all-cause mortality within 30 days, by cardiogenic shock or cardiac arrest · 30 days
Cangrelor vs No cangrelorRelative risk (95% CI)
cardiogenic shock, MACE; absolute risk reduction 8.9 percentage points (95% CI: 2.7-15); NNT = 12
0.82(0.71–0.94)
cardiogenic shock, mortality; absolute risk reduction 8.9 percentage points (95% CI: 2.7-15); NNT = 12
0.81(0.70–0.94)
cardiac arrest, MACE
1.01(0.87–1.18)
cardiac arrest, all-cause mortality
0.97(0.83–1.13)
Observational data: associations, not effects.
Safety
| Outcome | RR (95% CI) | |
|---|---|---|
| In-hospital major bleeding — Cangrelor vs No cangrelor · cardiogenic shock · PS-matched analysis | 1.60 (0.93–2.76) | |
| In-hospital major bleeding — Cangrelor vs No cangrelor · PS-matched analysis | 2.26 (1.25–4.11) | |
| 0.20.5125Relative risk (log scale) |
- In-hospital major bleeding: cardiac arrest; absolute risk increase 3.5 percentage points (95% CI: 1.0-5.7)
Original publication
Cangrelor During Percutaneous Coronary Intervention in Patients With Cardiogenic Shock or Cardiac Arrest. JACC Cardiovasc Interv. Published 14 April 2025. doi:10.1016/j.jcin.2025.01.451
Summarised from the published abstract; every number is checked against it