Heart failure & cardiomyopathies
Carbohydrate Antigen 125: A Useful Marker of Congestion, Fibrosis, and Prognosis in Heart Failure with Preserved Ejection Fraction
Main finding · Composite of all-cause mortality or first HF hospitalizationResult — go to the resultHazard ratio 1.58 CI 1.04–2.41Authors' conclusion
CA 125 levels were significantly higher in HFpEF patients compared with controls matched for age and sex and were associated with markers of congestion and cardiac fibrosis. CA 125 levels were a strong and independent predictor of HF hospitalization in HFpEF patients.
Study context
- Population
- Patients with HFpEF
- Participants
- 139 vs 25
- Exposure
- HFpEF patients vs matched controls; CA 125 ≥35 U/mL as predictor
- HFpEFn = 139
- Controlsn = 25reference
- Outcome
- Composite of:
- All-cause mortality
- First HF hospitalization
- Follow-up
- Median 49 (22-64) months
Methodological detailsage- and sex-matched controls
- Age- and sex-matched controls
Main finding
As reported in the abstract
Hazard ratio
1.58
CI 1.04–2.41
P = 0.032
Events by group
HFpEF
97
events
CA 125 ≥35 U/mL
HR 1.58 (CI 1.04–2.41); P = 0.032
Observational data: associations, not effects.
Further findings
Heart failure (HF) hospitalization
| HR (CI) | P value | ||
|---|---|---|---|
| CA 125 ≥35 U/mLAdjusted for MAGGIC risk score | 1.81 (1.13–2.92) | P = 0.014 | |
| 0.20.5125Hazard ratio (log scale) |
CA 125 level
P = 0.004
Correlations of CA 125
- N-terminal pro-brain natriuretic peptide (NT-proBNP), Pearson's r
- 0.37 (P < 0.001)
- Extracellular volume (ECV), Pearson's r
- 0.26 (P = 0.003)
- Fibroblast growth factor 23, Pearson's r
- 0.50 (P < 0.001)
Original publication
Carbohydrate Antigen 125: A Useful Marker of Congestion, Fibrosis, and Prognosis in Heart Failure with Preserved Ejection Fraction. ESC Heart Fail. Published 9 February 2024. doi:10.
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