Elevated Carbohydrate Antigen 125 (CA125) is Associated with Incident Heart Failure and Mortality in Acute Coronary Syndrome
Authors' conclusion
We report independent associations between elevated CA125, LV dysfunction, cardiac remodelling, incident HF and mortality post-ACS.
Study context
- Population
- Acute coronary syndrome (ACS) patients (73% males, mean age 67 ± 12 years)elderly subgroup n = 115
- Participants
- 524 patients
- Exposure
- Higher vs lower CA125
- Outcome
- Incident heart failure (HF) and mortality
- Follow-up
- Median 27.3 months for incident HF and 39.5 months for mortality
Main finding
As reported in the abstract
Hazard ratio (95% CI)P value
Baseline CA125 (per 1-SD increase)incident HF; adjusted for age, sex, CV risk factors, renal function, revascularization
1.46(1.10–1.93)
P = 0.009Baseline CA125 (per 1-SD)mortality; adjusted for age and sex
1.37(1.09–1.71)
P = 0.0066-week CA125 (per increasing tertile)mortality; adjusted for age and sex; elderly subgroup
1.98(1.06–3.67)
P = 0.0316-week CA125 (per increasing tertile)mortality; fully adjusted model; elderly subgroup
2.23(1.15–4.35)
P = 0.018Each row per its own increment, as printed
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| LVEF deterioration (>5% absolute decrease if LVEF ≥ 50% at discharge), elderly subgroup · 1 year post-ACS | 3.31 (1.15–9.54) | P = 0.027 | |
| 0.10.31310Odds ratio (log scale) |
Correlation of baseline CA125 with cardiac remodelling, elderly subgroup · 1 year post-ACS
- Left ventricular (LV) end-diastolic volume index, Spearman's r
- 0.329, P < 0.001
- LV end-systolic volume index, r
- 0.391, P < 0.001
- Left atrial volume index, r
- 0.320, P < 0.001
Original publication
Elevated Carbohydrate Antigen 125 (CA125) is Associated with Incident Heart Failure and Mortality in Acute Coronary Syndrome. ESC Heart Fail. Published 1 September 2024. doi:10.
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