Acute cardiac care & resuscitation
Carbon dioxide monitoring during neonatal stabilisation at delivery (COSTA-Neo)-multi centre observational study
Authors' conclusion
We have provided trends of ECO2 in preterm infants needing stabilisation during the first 10 minutes of life. ECO2 appeared at least as early as any valid PR and earlier than SpO2.
Study context
- Population
- Preterm infants ≤ 32 weeks needing stabilisation at birth131 analysed
- Participants
- 150 infants
- Outcome
- Trends of exhaled CO2 (ECO2) levels during stabilisation
- Follow-up
- First 10 minutes
Methodological detailsmulticentre, blinded ECO2 recording
- Multicentre
- Blinded ECO2 recording
Main finding
As reported in the abstract
ECO2 at 5 minutes · 5 minutes
ECO2 at 5 min, 50% CI (bootstrapping)
3.042 kPa1 to 3.328 kPa
Observational data: associations, not effects.
Further findings
Time of ECO2 appearance vs valid pulse rate (PR) and SpO2
- ECO2 earlier than valid PR, median time difference (s)
- 16 (2-22)
- ECO2 earlier than valid SpO2, median time difference (s)
- 14 (0-20)
Stabilisation interventions within first 10 minutes
- Positive pressure inflations
- 91 (69%)
- Only positive end expiratory pressure (PEEP)
- 34 (26%)
- Intubated
- 34 (26%)
- PEEP, all infants
Original publication
Carbon dioxide monitoring during neonatal stabilisation at delivery (COSTA-Neo)-multi centre observational study. Resuscitation. Published 27 October 2023. doi:10.
Summarised from the published abstract; every number is checked against it