Heart failure & cardiomyopathies
Cardiac involvement in non-cirrhotic portal hypertension: Magnetic resonance imaging (MRI) detects myocardial fibrosis and oedema similar to compensated cirrhosis
Authors' conclusion
MRI parameters of myocardial fibrosis and oedema were altered in participants with NCPH to a similar extent as in compensated cirrhosis and were associated with splenic markers of portal hypertension, indicating specific portal hypertensive cardiomyopathy.
Study context
- Population
- Participants with non-cirrhotic portal hypertension (NCPH), cirrhosis or no disease undergoing cardiac and abdominal MRI, 2018–2022
- Participants
- 111 participants
- Exposure
- NCPH vs cirrhotic controls vs healthy controls
- NCPHn = 44
- Cirrhotic controlsn = 47
- Healthy controlsn = 20reference
- Outcome
- Subclinical myocardial dysfunction, oedema and fibrosis on MRI
Methodological detailsmultiparametric abdominal and cardiac MRI
- Multiparametric abdominal and cardiac MRI
Main finding
As reported in the abstract
Myocardial fibrosis and oedema (MRI)
| Outcome | NCPH |
|---|---|
| LGE presence | 32% |
| Combined T1 and T2 elevations | 46% |
- Late gadolinium enhancement (LGE) presence across NCPH vs Child A vs Child B/C
- P = 0.004
- Combined T1 and T2 elevations across NCPH vs Child A vs Child B/C
- P = 0.017
Observational data: associations, not effects.
Further findings
Splenic T1 and presence of LGE
| OR (95% CI) | P value | ||
|---|---|---|---|
| Splenic T1 | 1.010 (1.002–1.019) | P = 0.013 | |
| 0.512Odds ratio (log scale) |
| Outcome | NCPH | Healthy controls |
|---|---|---|
| Hyperdynamic circulation (NCPH vs healthy controls) | ||
| Cardiac index | 3.7 ± 0.6 L/min/m² | 3.2 ± 0.8 L/min/m² |
| Global longitudinal strain | −27.3 ± 4.6% | −24.6 ± 3.5% |
- Hyperdynamic circulation (NCPH vs healthy controls) — Cardiac index NCPH vs healthy controls
- P = 0.004
- Hyperdynamic circulation (NCPH vs healthy controls) — Global longitudinal strain NCPH vs healthy controls
- P = 0.022
Splenic T1 vs myocardial T1 correlation
- Correlation r
- 0.41
- P
- P = 0.007
Original publication
Cardiac involvement in non-cirrhotic portal hypertension: MRI detects myocardial fibrosis and oedema similar to compensated cirrhosis. Eur Heart J Cardiovasc Imaging. Published 24 November 2022. doi:10.
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