Heart failure & cardiomyopathies
Cardiac Magnetic Resonance for Prophylactic Implantable-Cardioverter Defibrillator Therapy in Ischemic Cardiomyopathy: The DERIVATE-ICM International Registry
Main finding · MAACEResult — go to the resultNRI 31.7%Authors' conclusion
The DERIVATE-ICM registry is a large multicenter registry showing the additional value of CMR to stratify the risk for MAACE in a large cohort of patients with ICM compared with standard of care.
Study context
- Population
- Patients with ischemic cardiomyopathy, chronic HF and TTE-LVEF <50%
- Participants
- 861 patients
- Exposure
- Cardiac magnetic resonance (CMR) vs TTE for implantable cardioverter-defibrillator (ICD) indication
- Outcome
- Major adverse arrhythmic cardiac events (MAACE)
- Follow-up
- Median 1,054 days
Methodological detailsprognostic cohort study, international, multicenter, multivendor
- Prognostic cohort study
- International
- Multicenter
- Multivendor
Main finding
MAACE
Net reclassification improvement (NRI)
31.7%
P = 0.007
As reported in the abstract
- Major adverse arrhythmic cardiac events (MAACE) occurred
- 88 (10.2%)
- LV end-diastolic volume index, HR (95% CI 1.000-1.011), P = 0.05
- 1.007
- CMR-LVEF, HR (95% CI 0.945-0.999), P = 0.045
- 0.972
- Late gadolinium enhancement (LGE) mass, HR (95% CI 1.002-1.018), P = 0.015
- 1.010
Observational data: associations, not effects.
Original publication
Cardiac Magnetic Resonance for Prophylactic Implantable-Cardioverter Defibrillator Therapy in Ischemic Cardiomyopathy: The DERIVATE-ICM International Registry. JACC Cardiovasc Imaging. Published 24 May 2023. doi:10.
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