Heart failure & cardiomyopathies
Relationship between remnant cholesterol and risk of heart failure in participants with diabetes mellitus
Authors' conclusion
Elevated RC was significantly associated with risk of HF in patients with DM. Moreover, RC was significantly related to HF risk independent of LDL-C measures.
Study context
- Population
- Participants with diabetes mellitus (DM) from the UK Biobank2,232 heart failure (HF) events
- Participants
- 22,230 participants
- Exposure
- Moderate or high vs low remnant cholesterol
- Outcome
- HF
- Follow-up
- Mean 11.5 years
Methodological detailsUK Biobank
- UK Biobank
Main finding
As reported in the abstract
Each group vs low RCHazard ratio (95% CI)
Moderate RC
1.15(1.01–1.32)
High RC
1.23(1.05–1.43)
Observational data: associations, not effects.
Further findings
HF, remnant cholesterol (RC) as continuous measure
- RC as a continuous measure significantly related to increased HF risk
- P < 0.01
HF, by HbA1c (subgroup)
- Association stronger with HbA1c ≥ 53 mmol/mol than < 53 mmol/mol
- P for interaction = 0.02
HF, discordance analysis vs low-density lipoprotein cholesterol (LDL-C)
- RC significantly related to HF risk independent of LDL-C
Original publication
Relationship between remnant cholesterol and risk of heart failure in participants with diabetes mellitus. Eur Heart J Qual Care Clin Outcomes. Published 24 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →