Heart failure & cardiomyopathies
CarDiac magnEtic Resonance for prophylactic Implantable cardioVerter defibrillAtor ThErapy in Non-Dilated Left Ventricular Cardiomyopathy: a sub-study from the DERIVATE registry
Authors' conclusion
NDLVC patients exhibit a heterogeneous risk profile for arrhythmic events. The presence of midwall LGE, similarly to NIDCM, is a significant predictor of MAACE, highlighting the importance of CMR imaging for risk stratification.
Study context
- Population
- Patients with non-dilated left ventricular cardiomyopathy (NDLVC) from the DERIVATE registryNDLVC patients identified from the cohort of the DERIVATE study (mean age: 59 ± 14 years, male: 135)
- Participants
- 197 patients
- Comparison
- NDLVC subtypes compared with non-ischaemic dilated cardiomyopathy (NIDCM) patients; incremental value of cardiac magnetic resonance (CMR) imaging
- Primary endpoint
- All-cause mortality
- Follow-up
- Median 2.7 years
Methodological detailssub-study from the DERIVATE registry
- Sub-study from the DERIVATE registry
Primary result
As reported in the abstract
Patients died
15
8%
Secondary outcomes
Midwall late gadolinium enhancement (LGE) as predictor of major adverse arrhythmic cardiac events (MAACE) in NDLVC patients
| Hazard ratio (95% CI) | P value | ||
|---|---|---|---|
| LGE with midwall distributionMultivariable analysis; independent predictor · Multivariable analysis | 6.7 (1.33–33.67) | P = 0.021 | |
| 0.050.21520Hazard ratio (log scale) |
| Outcome | P value |
|---|---|
| MAACE (SCD and aborted SCD), secondary endpoint · median follow-up of 2.7 yearsHypokinetic NDLVC vs NIDCM · significantly lower rates of MAACE with hypokinetic NDLVC | P = 0.001 |
| MAACE (SCD and aborted SCD), secondary endpoint · median follow-up of 2.7 yearsFibrotic NDLVC vs NIDCM · same rate | P = 0.616 |
- MAACE (sudden cardiac death (SCD) and aborted SCD), secondary endpoint — Patients experienced MAACE
- 8 (4%)
Original publication
CarDiac magnEtic Resonance for prophylactic Implantable cardioVerter defibrillAtor ThErapy in Non-Dilated Left Ventricular Cardiomyopathy: a sub-study from the DERIVATE registry. Eur Heart J Cardiovasc Imaging. Published 3 February 2025. doi:10.
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