Heart failure & cardiomyopathies
Cardiac magnetic resonance for prophylactic implantable-cardioverter defibrillator therapy international study: prognostic value of cardiac magnetic resonance-derived right ventricular parameters substudy
Primary result · All-cause mortalityResult — go to the resultAdjusted hazard ratio 1.44 95% CI 1.09–1.91Authors' conclusion
RV systolic dysfunction is an independent predictor of ACM in HFrEF, with a more pronounced prognostic value in select subgroups, likely reflecting the importance of RVSD in the early stages of HF progression.
Study context
- Population
- Patients with HF with reduced ejection fraction (HFrEF) with simultaneous baseline cardiac magnetic resonance (CMR) and echocardiography
- Participants
- 2,449 patients
- Comparison
- Right ventricular systolic dysfunction (RVSD) vs no RVSD
- RVSDn = 936
- Primary endpoint
- All-cause mortality
- Follow-up
- Median 959 days (IQR 560-1590)
Methodological detailsinternational
- International
Primary result
As reported in the abstract
Adjusted hazard ratio
1.44
95% CI 1.09–1.91
P = 0.01
RVSDvs No RVSD
adjusted HR 1.44 (95% CI 1.09–1.91); P = 0.01
Further findings
All-cause mortality, by subgroup
- Prognostic value of RVSD more pronounced in NYHA I/II than NYHA III/IV, in left ventricular ejection fraction (LVEF) <35% than LVEF ≥35%, and in renal dysfunction than normal renal function
Original publication
Cardiac magnetic resonance for prophylactic implantable-cardioverter defibrillator therapy international study: prognostic value of cardiac magnetic resonance-derived right ventricular parameters substudy. Eur Heart J Cardiovasc Imaging. Published 6 July 2022. doi:10.
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