Cardiac Medication Prescription Pattern and Association With Transplant-free Survival in the Adult Fontan Population
Authors' conclusion
We report one of the first large-scale studies of prescription patterns in adult patients with Fontan circulation in a single ACHD clinic. We demonstrate an inverse association between loop diuretic prescriptions and transplant-free survival.
Study context
- Population
- Adults with Fontan circulation followed in an outpatient adult congenital heart disease (ACHD) clinic between 2009 and 2023patients (55.2% male, 72.5% White, 49.7% single left ventricle morphology), median age 24 years (IQR: 22–29) at first clinic visit
- Participants
- 429 adults
- Exposure
- Association between medication type/burden and transplant-free survival
- Outcome
- Prescribed medication classes
Methodological detailssingle ACHD clinic, Cox proportional hazards analysis
- Single ACHD clinic
- Cox proportional hazards analysis
Main finding
As reported in the abstract
- Antiplatelet agents
- 74.6%
- Angiotensin converting enzyme inhibitors or angiotensin receptor blockers
- 59.0%
- Anticoagulants
- 44.1%
- Loop diuretics
- 39.6%
- Metoprolol
- 32.2%
- Mineralocorticoid receptor antagonists
- 31.5%
- Antiarrhythmics
- 27.5%
- Pulmonary vasodilators
- 16.1%
Observational data: associations, not effects.
Further findings
| Outcome | HR | P value |
|---|---|---|
| Transplant-free survivalAssociated with worse transplant-free survival | 9.49 | P < 0.001 |
Original publication
Cardiac Medication Prescription Pattern and Association With Transplant-free Survival in the Adult Fontan Population. JACC Adv. Published 20 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →