Congenital heart diseaseCohort study
The Fontan Adult Brompton clinical score and mortality risk
- Retrospective cohort study
- single tertiary centre
- external validation cohort
Authors' conclusion
This novel, readily available, externally validated, clinical score identifies adult patients with a Fontan palliation at risk of mortality or transplantation
Study context
- Population
- Adults with a Fontan circulation at their first adult congenital heart disease outpatient visit
- Outcome
- Death or heart transplantation (prognostic score discrimination)
Main finding
As reported in the abstract
Discrimination of clinical score (age at first visit, atrial tachyarrhythmia, HF, NYHA class, SBP, resting arterial oxygen saturation) for death or transplantation
| Group | C-index |
|---|---|
| Derivation | 0.71 (95% CI 0.62-0.80) |
| Validation | 0.92 (95% CI 0.90-0.95) |
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Freedom from transplantation survival, validation vs derivation cohort · log-rank; similar | P = 0.77 |
Deaths and heart transplantation (derivation cohort) · within 10.2 years of follow-up
- Deaths
- 44
- Heart transplantation
- 2
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The Fontan Adult Brompton clinical score and mortality risk. Eur Heart J. Published 25 March 2025. doi:10.1093/eurheartj/ehaf137
Summarised from the published abstract; every number is checked against it