Neonatal outcomes of pregnancy in women with congenital heart disease
Authors' conclusion
Nearly half of infants born to women with CHD experienced the adverse composite neonatal outcome, with the highest risk among those born to women with severe CHD. In addition to CHD severity, risk factors for adverse neonatal outcomes among women with CHD included black race, hypertensive disorders of pregnancy, PGDM, prior preterm birth and non-singleton pregnancy. These findings can help provide individualized counseling about neonatal risks for women with CHD.
Study context
- Population
- Women with congenital heart disease (CHD) who had a live birth from 2011 through 2014 in geographic areas in Georgia, North Carolina and Utah, and their liveborn infantsliveborn infants born to 1,982 women with CHD (34% with severe CHD)
- Participants
- 2,411 women
- Comparison
- Infants born to mothers with severe CHD
- Outcome
- Neonatal outcomes (all infants)
Methodological detailsCDC Lifespan CHD surveillance project, linked birth certificates, logistic regression fit using generalized estimating equations clustered on mother
- CDC Lifespan CHD surveillance project
- Linked birth certificates
- Logistic regression fit using generalized estimating equations clustered on mother
Main finding
As reported in the abstract
- Preterm
- 19%
- Low birth weight
- 18%
- Small for gestational age (SGA)
- 14%
- Diagnosed with CHD
- 4.2%
- Required neonatal intensive care unit (NICU)
- 25%
- Composite adverse outcome
- 40%
Further findings
| Outcome | aOR (CI) | |
|---|---|---|
| Composite adverse outcome | 2.1 (1.8–2.5) | |
| CHD recurrence | 17.1 (9.3–31.5) | |
| Risk factors for the composite adverse outcome (multivariable analysis)Severe CHDvs non-severe | 2.2 (1.8–2.7) | |
| Risk factors for the composite adverse outcome (multivariable analysis)Black racevs White | 1.8 (1.4–2.3) | |
| 0.050.21520Adjusted odds ratio (log scale) |
Risk factors for the composite adverse outcome (multivariable analysis)
| aOR (CI) | ||
|---|---|---|
| PGDM | 2.5 (1.3–5.0) | |
| Hypertensive disorder of pregnancy | 2.1 (1.5–3.1) | |
| Prior preterm birth | 2.0 (1.3–3.1) | |
| Non-singleton pregnancy | 6.7 (3.8–11.6) | |
| 0.050.21520Adjusted odds ratio (log scale) |
- Risk factors for the composite adverse outcome (multivariable analysis): associated with increased risk of the composite adverse outcome
Original publication
Neonatal outcomes of pregnancy in women with congenital heart disease. Am Heart J. Published 18 August 2025. doi:10.
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