Heart failure & cardiomyopathies
Cardiac Resynchronization Therapy in Heart Failure Based on Strauss Criteria for Left Bundle Branch Block
Authors' conclusion
Patients with NICM and St-LBBB present the greatest benefit concerning CRT response, HF hospitalizations, VA events and mortality.
Study context
- Population
- Heart failure (HF) patients with left bundle branch block (LBBB) (ischaemic and non-ischaemic cardiomyopathy) admitted for cardiac resynchronization therapy (CRT) implantation
- Participants
- 82 patients
- Exposure
- Strauss-criteria LBBB vs non-Strauss LBBB in CRT recipients
- St-LBBBn = 46
- non-St-LBBBn = 36reference
- Outcome
- CRT response
Main finding
As reported in the abstract
- Higher CRT response rates with St-LBBB vs non-St-LBBB
- P < 0.01
- Greatest benefit in non-ischaemic (NICM)
- P < 0.01
Observational data: associations, not effects.
Further findings
HF hospitalization
- Lower HF hospitalization in St-LBBB CRT responders vs non-St-LBBB
- P < 0.0001
- Primarily evident in NICM (Kaplan-Meier)
- P < 0.0001
Ventricular arrhythmia (VA) events
- Fewer VA events in CRT responders vs non-responders
- P < 0.001
- Lower VA incidence in NICM with St-LBBB (Kaplan-Meier)
- P = 0.049
- Ischaemic (ICM) with St-LBBB
- P = 0.25
Mortality
- Lower mortality in CRT responders vs non-responders
- P < 0.0001
- Greatest benefit in NICM with St-LBBB
- P = 0.0238
Original publication
Cardiac Resynchronization Therapy in Heart Failure Based on Strauss Criteria for Left Bundle Branch Block. ESC Heart Fail. Published 20 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →