Heart failure & cardiomyopathies
Early Diagnosis, Disease Stage and Prognosis in Wild-Type Transthyretin Amyloid Cardiomyopathy: The DIAMOND Study
Authors' conclusion
In this contemporary nationwide cohort, an ATTRwt-CA early diagnosis was very rare. Disease staging with NAC and Columbia scoring systems determined classes of patients with heterogeneous features. Both scores were significantly associated with mortality, but other variables also had prognostic significance.
Study context
- Population
- Patients with ATTRwt-CA diagnosed 2016–2021 at Italian referral centres (DIAMOND)of 1281 enrolled
- Participants
- 811 patients
- Outcome
- Prevalence of early diagnosis (NAC Ia, NYHA I, no diuretics, no prior HF hospitalisation or AF); prognosis as all-cause mortality
Methodological detailsmulticentre, 17 Italian referral centres
- Multicentre
- 17 Italian referral centres
Main finding
As reported in the abstract
Early ATTRwt-CA diagnosis
Prevalence of early diagnosis
1%
Observational data: associations, not effects.
Further findings
NAC and Columbia classes by diagnostic pathway
- Higher prevalence of NAC III and Columbia III in HF pathway; all classes present in all pathways
Original publication
Early Diagnosis, Disease Stage and Prognosis in Wild-Type Transthyretin Amyloid Cardiomyopathy: The DIAMOND Study. ESC Heart Fail. Published 20 September 2024. doi:10.
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