Arrhythmias & electrophysiology
Cardiac sympathetic denervation for refractory ventricular arrhythmias in patients with inherited cardiomyopathies
Authors' conclusion
Bilateral CSD significantly reduced implantable cardioverter-defibrillator shocks in patients with inherited cardiomyopathies, demonstrating durable arrhythmia control and favorable long-term transplant-free survival across diverse genetic subtypes.
Study context
- Population
- Adults with refractory ventricular arrhythmia (VA) and an inherited cardiomyopathy referred for cardiac sympathetic denervation (CSD), minimum 12-month postoperative follow-up, 2010–2023
- Participants
- 23 adults
- Exposure
- Pre- vs post-bilateral CSD
- Hypertrophic cardiomyopathyn = 7
- Arrhythmogenic cardiomyopathyn = 11
- Dilated cardiomyopathyn = 5
- Outcome
- Overall success rate of bilateral CSD; ICD shocks pre- vs post-CSD
- Follow-up
- Median 34.5 months (IQR 23.1-46.5)
Methodological detailsmulticentre, 4 tertiary referral centres
- Multicentre
- 4 tertiary referral centres
Main finding
As reported in the abstract
Overall success rate of CSD
48%
ICD shocks decreased, pre- vs post-CSD (P < .01)
61%
Observational data: associations, not effects.
Safety
Expected complications
- Most resolved upon follow-up
Original publication
Cardiac sympathetic denervation for refractory ventricular arrhythmias in patients with inherited cardiomyopathies. Heart Rhythm. Published 31 October 2025. doi:10.
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