Heart failure & cardiomyopathies
Cardioimmunologic Response Patterns After an Acute Heart Failure Event: Design and First Results of AHF-ImmunoCS
Authors' conclusion
Our preliminary data confirm that seroconversion to HRAs occurs early after hospitalization for HF in a subgroup of patients.
Study context
- Population
- Patients hospitalised for acute heart failure (HF)enrolled by 31 Dec 2023
- Participants
- 259 patients
- Outcome
- Baseline characteristics and timing of seroconversion to heart-reactive antibodies (HRAs)
Methodological detailsmonocentric, consecutive enrolment, Follow-up at 6 weeks, 6, 12 and 18 months, HRA screening by immunofluorescence testing and bead-immobilised cardiac antigens
- Monocentric
- Consecutive enrolment
- Follow-up at 6 weeks, 6, 12 and 18 months
- HRA screening by immunofluorescence testing and bead-immobilised cardiac antigens
Main finding
As reported in the abstract
- Women
- 38%
- Age, mean (SD), years
- 72 (SD 13)
- De novo HF
- 37%
- LVEF, median (quartiles), %
- 50 (quartiles 35, 56)
- Seroconverters who did so within 6 weeks (preliminary data, first 59 patients)
- 80%
Observational data: associations, not effects.
Original publication
Cardioimmunologic Response Patterns After an Acute Heart Failure Event: Design and First Results of AHF-ImmunoCS. ESC Heart Fail. Published 30 October 2025. doi:10.
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