Arrhythmias & electrophysiology
Predictors of Clinical Success of Cardioneuroablation in Patients With Syncope: Results of a Multicenter Study
Authors' conclusion
In this multicenter study, the effectiveness of CNA was less than previously reported. We found a 3.9% risk of SND. Male sex, age >50 years, cardioinhibitory syncope, general anesthesia or deep sedation, and >30 radiofrequency applications could predict success of CNA for syncope.
Study context
- Population
- Patients with reflex cardioinhibitory or mixed syncope, functional sinus node dysfunction (SND) or functional AV block treated with cardioneuroablation (CNA), ≥6 months follow-up
- Participants
- 77 patients · 22 hospitals
- Exposure
- Predictors of syncope recurrence after CNA
- Outcome
- Recurrence of syncope after CNA
- Follow-up
- Median 12 months (Q1-Q3: 8-20 months)
Methodological details22 hospitals
- 22 hospitals
Main finding
As reported in the abstract
Syncope recurrence · median 12 months
Hazard ratio (95% CI)P value
Women vs Menadjusted
3.3(1.2–8.8)
P = 0.016>50 years vs Youngeradjusted
0.3(0.1–0.9)
P = 0.032Mixed syncope vs Cardioinhibitory syncopeadjusted
4.4(1.1–17.5)
P = 0.033General anesthesia or deep sedation vs Conscious sedationadjusted
0.2(0.1–0.6)
P = 0.002Radiofrequency applications (≤30 or >30)association with CNA success; adjusted
0.4(0.2–0.9)
P = 0.042- Recurrence of syncope
- 26 (33.8%)
Observational data: associations, not effects.
Safety
- Patients with complications
- 5 (6.5%)
- SND
- 3
- Pacemaker required
- 1
- Risk of SND
- 3.9%
Original publication
Predictors of Clinical Success of Cardioneuroablation in Patients With Syncope: Results of a Multicenter Study. JACC Clin Electrophysiol. Published 23 October 2024. doi:10.
Summarised from the published abstract; every number is checked against it