Arrhythmias & electrophysiology
Clinical impact of aging on outcomes of cardioneuroablation for reflex syncope or functional bradycardia: Results from the cardionEuroabLation: patiEnt selection, imaGe integrAtioN and outComEs—The ELEGANCE multicenter study
Authors' conclusion
CNA is a viable treatment for reflex syncope and functional bradyarrhythmia in all ages, and is highly effective in mixed VVS.
Study context
- Population
- Patients undergoing cardioneuroablation (CNA) for reflex syncope (VVS, carotid sinus syndrome) or severe functional bradyarrhythmia37 men
- Participants
- 60 patients
- Exposure
- CNA outcomes by age group: young vs middle-aged vs older
- Youngn = 14
- Middle-agedn = 26
- Oldern = 20
- Outcome
- CNA candidacy and efficacy by age group
Main finding
As reported in the abstract
Acute CNA success
Acute CNA success, overall
93%
No differences between age groups
P = .42
Observational data: associations, not effects.
Further findings
Post-CNA HUT response
- Negative
- 53%
- Vasodepressor
- 38%
- Cardioinhibitory
- 7%
- Mixed
- 2%
- No differences across age groups
- P = 0.59
Freedom from symptoms · 8 months, interquartile range 4-15
- Free of symptoms, overall
- 53 (88%)
- No differences in event-free survival between age groups (Kaplan-Meier)
- P = 0.29
NPV of a negative post-CNA HUT
- NPV
- 91.7%
Pre-CNA Holter electrocardiography (ECG), HUT and electrophysiological findings
- Did not differ across age groups
Original publication
Clinical impact of aging on outcomes of cardioneuroablation for reflex syncope or functional bradycardia: Results from the cardionEuroabLation: patiEnt selection, imaGe integrAtioN and outComEs—The ELEGANCE multicenter study. Heart Rhythm. Published 15 June 2023. doi:10.
Summarised from the published abstract; every number is checked against it