Cardio-oncology & other

Cardiopulmonary long-term effects 30 months after severe COVID-19 infection

Eur Heart J Qual Care Clin OutcomesPublished prospective multicenter cohort study

Authors' conclusion

Even though cardiopulmonary functional and structural abnormalities regressed over time, almost half of the patients still suffered from Long COVID at 30 months. The disconnect between pathological cardiopulmonary findings and reported symptoms, continues to pose a persistent clinical challenge in the understanding and managing Long COVID.

Study context

Population
Patients hospitalized between February 2020 and October 2021 with a PCR-confirmed COVID-19 infectioncompleted 6-month follow-up, those with pathological findings on cardiopulmonary imaging received additional follow-ups · 18-month follow-up 170 · 30-month follow-up 139
Participants
200 patients
Outcome
Reduced left ventricular function
Follow-up
30 months

Main finding

As reported in the abstract

Persistent mild impairment at 30 months (patients with previously reduced left ventricular function)
two patients
6 months
n = 15 (8%)

Observational data: associations, not effects.

Further findings

Pericardial effusion · 30 months

6 months
n = 28 (17%)
Resolved in all patients but one

Signs of pericarditis and myocarditis · 18 months

6 months
n = 7 (5%)
Already regressed at the 18-month follow-up

Chest computed tomography (CT) abnormalities · 30 months

Complete resolution at 30 months
one patient
Remaining patients with minor fibrotic and scarred tissue, 30 months
n = 17 (94%)
6 months
n = 41 (24%)

Long COVID incidence · 6 and 30 months

6 months
73%
30 months
49%
No clear predictors identified

Original publication

Cardiopulmonary long-term effects 30 months after severe COVID-19 infection. Eur Heart J Qual Care Clin Outcomes. Published 30 May 2025. doi:10.1093/ehjqcco/qcaf035

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