Aortic & peripheral vascular diseaseCohort study
Cardiovascular Events After Aortic Root Repair in Patients With Marfan Syndrome
- Prospective cohort study
Authors' conclusion
Aortic valve sparing operations provide stable aortic valve function and low rates of valve-related complications during the first 2 decades of follow-up but aortic dissections remain problematic in patients with MS.
Study context
- Population
- Patients with Marfan syndrome who underwent aortic valve sparing operations (reimplantation or remodeling), 1988–201952 at risk at 20 years
- Participants
- 189 patients
- Outcome
- Cardiovascular events
Main finding
As reported in the abstract
20 years
Mortality
21.5% (95% CI 14.7%-30.8%)
Cumulative incidence of moderate or severe aortic insufficiency
14.5% (95% CI 9.5%-22.0%)
Reoperation on the aortic valve
7.5% (95% CI 3.9%-14.7%)
New distal aortic dissections
19.9% (95% CI 13.9%-28.5%)
Observational data: associations, not effects.
Further findings
Predictors of death
- Advancing age and preoperative aortic dissections associated with increased risk of death (multivariable analysis)
Aortic insufficiency and aortic valve reoperation, by technique
- Remodeling of aortic root associated with greater risk than reimplantation of the aortic valve
Original publication
Cardiovascular Events After Aortic Root Repair in Patients With Marfan Syndrome. J Am Coll Cardiol. Published 12 September 2023. doi:10.1016/j.jacc.2023.06.032
Summarised from the published abstract; every number is checked against it