Aortic & peripheral vascular diseaseCohort study
Sex-Specific Cardiovascular Phenotypes in Marfan Syndrome
- retrospective cohort study
- manual chart and imaging report review
- multivariable logistic regression
- sensitivity analyses in the genetically positive subgroup
Authors' conclusion
In this multicenter Marfan cohort, men had a greater burden of aneurysmal disease, atrial arrhythmias, sustained ventricular tachycardia, and aortic intervention, whereas dissection prevalence was similar between sexes.
Study context
- Population
- Adults with confirmed marfan syndrome (MFS) evaluated from 2018 to 2024 at Mayo Clinicmen 443 · women 340
- Participants
- 783 patients
- Exposure
- men and women with confirmed MFS
- menn = 443
- womenn = 340
Main finding
As reported in the abstract
ascending aortic aneurysm
Observational data: associations, not effects.
Further findings
any aneurysm
any extra-aortic aneurysm
atrial fibrillation
atrial flutter
sustained ventricular tachycardia
aortic root surgery
mitral valve prolapse
- any aneurysm: all P ≤ 0.001
- any extra-aortic aneurysm: all P ≤ 0.001
- atrial fibrillation: all P < 0.05
- atrial flutter: all P < 0.05
- sustained ventricular tachycardia: all P < 0.05
- aortic root surgery: all P < 0.05
- mitral valve prolapse: P = 0.028
Dissection prevalence
- Dissection prevalence was similar by sex
aneurysmal burden, atrial fibrillation, sustained ventricular tachycardia, and aortic root surgery (adjusted)
- After adjustment, male sex remained associated with aneurysmal burden, atrial fibrillation, sustained ventricular tachycardia, and aortic root surgery
Original publication
Sex-Specific Cardiovascular Phenotypes in Marfan Syndrome. JACC Adv. Published 20 July 2026. doi:10.1016/j.jacadv.2026.103034
Summarised from the published abstract; every number is checked against it