Heart failure & cardiomyopathies
Cardiovascular Measures of All-Cause Mortality in Duchenne Muscular Dystrophy
Authors' conclusion
LV ejection fraction, indexed LV volumes, circumferential strain, late gadolinium enhancement full width half maximum, and NT-proBNP are associated with all-cause mortality in DMD
Study context
- Population
- Patients with Duchenne muscular dystrophy (DMD)
- Participants
- 78 patients211 CMR studies
- Outcome
- All-cause mortality
Main finding
As reported in the abstract
Measures associated with all-cause mortality
- Deaths
- 15 (19%)
- LVEF, indexed left ventricular (LV) end diastolic and systolic volumes, LGE full width half maximum and circumferential strain associated with all-cause mortality
- P<0.05
- NT-proBNP the only blood biomarker associated with all-cause mortality
- P<0.05
Observational data: associations, not effects.
Further findings
Change over time of CMR measures · 1 and 2 years
- LVEF, indexed end systolic volumes, global severity score and full width half maximum worsened at 1 and 2 years
- Circumferential strain and indexed LV end diastolic volumes worsened at 2 years
Original publication
Cardiovascular Measures of All-Cause Mortality in Duchenne Muscular Dystrophy. Circ Heart Fail. Published 8 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →