Heart failure & cardiomyopathies
Boys With Duchenne Muscular Dystrophy Have Diastolic Dysfunction Based on Cardiac Magnetic Resonance (CMR)
Authors' conclusion
Patients with DMD have significantly different baseline CMR filling and ejection indices compared with controls. Some filling indices are associated with mortality and may be useful prognostic measures.
Study context
- Population
- Boys with Duchenne muscular dystrophy and healthy controls undergoing CMR
- Participants
- 179 vs 96
- Exposure
- Duchenne muscular dystrophy (DMD) vs healthy controls
- DMDn = 179
- Healthy controlsn = 96reference
- Outcome
- CMR LV filling and ejection measures
- Follow-up
- Baseline CMR
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
baseline
- DMD vs Healthy controls: P < 0.001
- DMD vs Healthy controls: P < 0.001
- DMD vs Healthy controls: P = 0.011
Observational data: associations, not effects.
Further findings
Baseline stature, ventricular volumes and LVEF
- DMD: smaller stature and ventricular volumes vs controls
- P < 0.001
- DMD: lower LVEF vs controls, though most had normal systolic function
- P < 0.001
Association with mortality in DMD (Cox, adjusted for heart rate; normalized to left ventricular (LV) end-diastolic volume)
- Lower peak ventricular ejection rate associated with mortality
- P = 0.007
- Lower peak filling rate associated with mortality
- P = 0.033
Original publication
Boys With Duchenne Muscular Dystrophy Have Diastolic Dysfunction Based on CMR. Circ Cardiovasc Imaging. Published 4 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →