Cardiovascular morbidity and mortality after radiotherapy for breast cancer: a systematic review and meta-analysis
Pooled result · HFResult — go to the resultHazard ratio 1.37 95% CI 1.20–1.57Authors' conclusion
Radiotherapy for breast cancer was associated with an increased risk of experiencing adverse cardiovascular events, which was highly dependent on the cardiac irradiation dose.
Study context
- Population
- Patients with breast cancer treated with or without radiotherapy
- Participants
- 610,690 patients31 studies
- Comparison
- Radiotherapy vs no radiotherapy for breast cancer
- Outcome
- HF
Methodological detailsrandom-effects meta-analysis
- Random-effects meta-analysis
Pooled result
As reported in the abstract
Hazard ratio
1.37
95% CI 1.20–1.57
Radiotherapyvs No radiotherapy
HR 1.37 (95% CI 1.20–1.57)
Further pooled results
CAD, left-sided vs other radiotherapy (irradiated patients)
| HR (95% CI) | ||
|---|---|---|
| Left-sided radiotherapy | 1.11 (1.05–1.16) | |
| 0.512Hazard ratio (log scale) |
Cardiac morbidity by mean heart exposure dose (linear correlation)
| HR (95% CI) | ||
|---|---|---|
| Mean heart exposure dose | 1.12 (1.05–1.19) | |
| 0.512Hazard ratio (log scale) |
Cardiac mortality with left-sided radiotherapy, by treatment period
- Risk decreased after 1989 (HR 1.30 vs 1.02)
- P < 0.01*
Publication bias
- No evidence of significant publication bias
Original publication
Cardiovascular morbidity and mortality after radiotherapy for breast cancer: a systematic review and meta-analysis. Heart. Published 10 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →