Prognostic Value of Exercise Stress Echocardiography for Patients With Breast Cancer Treated With Chest Radiotherapy
Authors' conclusion
An ischemic ESE predicts CVD + NFMI and MACE in patients with breast cancer treated with chest radiotherapy, independent of cardiovascular comorbid conditions and aerobic capacity.
Study context
- Population
- Breast cancer survivors treated with chest radiotherapy who underwent exercise stress echocardiography (ESE), 2000–2020
- Participants
- 507 survivors
- Exposure
- Ischemic ESE vs normal ESE
- Ischemic ESEn = 76
- Outcome
- CV death and nonfatal MI (CVD + NFMI), MACE and all-cause mortality
- Follow-up
- Median 7.8 (IQR 4.9-10.8) years
Main finding
As reported in the abstract
Ischemic ESE vs Normal ESEHazard ratio (95% CI)
CVD + NFMI; adjusted for CV risk factors, METs achieved and cardiotoxic chemotherapy
2.25(1.05–4.76)
MACE; adjusted for CV risk factors, METs achieved and cardiotoxic chemotherapy
3.62(2.07–6.32)
All-cause mortality; not increased
1.33(0.78–2.26)
- Total events: CVD + NFMI
- 35
- Total events: Major adverse cardiac events (MACE)
- 61
- Total events: deaths
- 80
Observational data: associations, not effects.
Original publication
Prognostic Value of Exercise Stress Echocardiography for Patients With Breast Cancer Treated With Chest Radiotherapy. JACC Adv. Published 16 September 2025. doi:10.
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