Arrhythmias & electrophysiologyMeta-analysis
Cardiovascular prognostic impact of missense vs nonmissense lamin A/C variants: A systematic review and meta-analysis
- systematic review and meta-analysis
- fixed or random effects models, depending on heterogeneity
Authors' conclusion
Nonmissense LMNA variants are associated with worse cardiovascular outcomes, particularly arrhythmic events, whereas HF-related events seem comparable between nonmissense and missense variants.
Study context
- Population
- Patients with missense vs nonmissense variants in the LMNA genemissense variants 969 · nonmissense variants 849
- Participants
- 1,818 patients · 12 studies
- Comparison
- missense vs nonmissense variants in the LMNA gene
- missensen = 969reference
- nonmissensen = 849
- Outcome
- Cardiovascular outcome defined as combined malignant ventricular arrhythmias (MVAs) and HF
Pooled result
As reported in the abstract
Odds ratio
2.22
P < 0.001
By group
Further pooled results
MVAs (secondary) · more frequent in nonmissense carriers
OR 2.37 · P < 0.001
HF-related severe events (secondary) · seemed similar between the groups
OR 0.956 · P = 0.801
- Heart failure (HF)-related severe events (secondary): limited by the small number of studies (n = 5) and single-study bias
Original publication
Cardiovascular prognostic impact of missense vs nonmissense lamin A/C variants: A systematic review and meta-analysis. Heart Rhythm. Published 5 January 2026. doi:10.1016/j.hrthm.2025.12.038
Summarised from the published abstract; every number is checked against it