Heart failure & cardiomyopathies
Cardiovascular vs. Non-Cardiovascular Deaths After Heart Failure Hospitalization in Young, Older, and Very Old Patients
Authors' conclusion
The probability of a non-CVD increases in both LVEF categories with advancing age, but that it is greater in the HFpEF category.
Study context
- Population
- Patients hospitalized with heart failure (HF); age groups young (<65 years), older (65–84 years), very old (≥85 years)39.7% women
- Participants
- 3,558 patients
- Exposure
- Non-HFpEF vs HF with preserved EF (HFpEF), by age group
- HFpEFn = 1,505reference
- non-HFpEFn = 2,053
- Outcome
- CV death and non-CV death by age and LVEF category
- Follow-up
- Median 2 years
Methodological detailsconsecutively registered, central adjudication of events, Adverse events adjudicated by central committee
- Consecutively registered
- Central adjudication of events
- Adverse events adjudicated by central committee
Main finding
As reported in the abstract
Proportion of deaths that were CV
Young
Older
Very old
Observational data: associations, not effects.
Further findings
Crude incidence of all-cause death, by age
Young
log-rank P = 0.10
Older
log-rank P = 0.002
Very old
log-rank P = 0.043
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| HF readmission and subsequent all-cause deathHF readmissionvs no HF readmissionnon-HFpEF | 1.72 (1.41–2.09) | P < 0.001 | |
| HF readmission and subsequent all-cause deathHF readmissionvs no HF readmissionHFpEF | 1.12 (0.87–1.43) | P = 0.39 | |
| 0.512Hazard ratio (log scale) |
Original publication
Cardiovascular vs. Non-Cardiovascular Deaths After Heart Failure Hospitalization in Young, Older, and Very Old Patients. ESC Heart Fail. Published 27 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →