Arrhythmias & electrophysiology
Catheter ablation for atrial fibrillation in patients with significant mitral regurgitation: A systematic review and meta-analysis
Pooled result · AF recurrence after catheter ablationResult — go to the resultHazard ratio 2.47 95% CI 1.52–4.01Authors' conclusion
Baseline significant MR was independently predictive of AF recurrence rate after CA. Despite the increased AF recurrence rates after CA associated with significant MR, CA with maintenance of sinus rhythm appeared to improve the severity of MR, suggesting a possible induction of reverse positive atrial and mitral valvular remodeling.
Study context
- Population
- Patients undergoing catheter ablation for atrial fibrillation (AF), with or without significant mitral regurgitation
- Participants
- 2,624 patients17 studies
- Comparison
- Significant mitral regurgitation (MR) vs no significant MR in patients undergoing catheter ablation for AF
- Outcome
- AF recurrence after catheter ablation
Pooled result
As reported in the abstract
Hazard ratio
2.47
95% CI 1.52–4.01
P < 0.001
By group
Significant MRvs Without significant MR
HR 2.47 (95% CI 1.52–4.01); P < 0.001
Further pooled results
- MR improvement to nonsignificant (<moderate) or resolution after catheter ablation — Significant MR
- pooled proportion 46 % (95% CI 30%–62%)
Original publication
Catheter ablation for atrial fibrillation in patients with significant mitral regurgitation: A systematic review and meta-analysis. Heart Rhythm. Published 31 July 2024. doi:10.
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