Arrhythmias & electrophysiology
Catheter ablation is associated with reduced cardiovascular events in atrial fibrillation patients with atrial functional mitral regurgitation
Authors' conclusion
In patients with AF and moderate or severe AFMR, CA was associated with fewer cardiovascular events in this observational study explicitly emulating a target trial, and these findings require confirmation in randomized controlled trials.
Study context
- Population
- Patients with atrial fibrillation (AF) and moderate or greater atrial functional mitral regurgitation (AFMR), China-AF registry
- Participants
- 873 patients
- Exposure
- Catheter ablation vs medical therapy
- Catheter ablation (CA)n = 484
- Medical therapy (MT)n = 389reference
- Outcome
- Cardiovascular events (primary outcome)
- Follow-up
- Median 1509 days
Methodological detailstarget trial emulation, stabilized inverse probability of treatment weighting, intention-to-treat
- Target trial emulation
- Stabilized inverse probability of treatment weighting
- Intention-to-treat
Main finding
As reported in the abstract
Primary outcome
CA
22
events
MT
42
events
Each group vs MTWeighted hazard ratio (95% CI)
CA
0.55(0.32–0.94)
- CA
- absolute risk difference −1.54 %
Observational data: associations, not effects.
Further findings
| Outcome | Weighted HR (95% CI) | |
|---|---|---|
| AF recurrence | 0.31 (0.25–0.37) | |
| CV death | 0.48 (0.24–0.96) | |
| All-cause death | 0.49 (0.27–0.89) | |
| 0.20.5125Weighted hazard ratio (log scale) |
Ischemic stroke/systemic embolism, CV hospitalization
- No significant differences
Sensitivity analyses and exploratory subgroups
- Consistent directional trends
Safety
Major bleeding
- No significant difference
Original publication
Catheter ablation is associated with reduced cardiovascular events in atrial fibrillation patients with atrial functional mitral regurgitation. Heart Rhythm. Published 1 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →