Arrhythmias & electrophysiology

Catheter ablation versus medical therapy for atrial fibrillation in patients with heart failure with preserved ejection fraction: A systematic review and meta-analysis

Heart RhythmPublished Systematic review and meta-analysis of randomised trial-derived and observational studies

Pooled result · Death or HF hospitalization (composite)Result — go to the resultHazard ratio 0.62 95% CI 0.47–0.83

Authors' conclusion

In this meta-analysis, catheter ablation was associated with a lower risk of all-cause death, cardiovascular death, HF hospitalization, and all-cause rehospitalization in comparison to medical therapy in patients with AF and HFpEF.

Study context

Population
Patients with atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF)
Participants
20,257 patients8 studies
Comparison
Catheter ablation vs medical therapy
Outcome
Death or heart failure (HF) hospitalization (composite)

Pooled result

As reported in the abstract

Hazard ratio

0.62

95% CI 0.47–0.83

P = 0.001

Catheter ablationvs Medical therapy
HR 0.62 (95% CI 0.47–0.83); P = 0.001

Original publication

Catheter ablation versus medical therapy for atrial fibrillation in patients with heart failure with preserved ejection fraction: A systematic review and meta-analysis. Heart Rhythm. Published 15 April 2024. doi:10.1016/j.hrthm.2024.04.058

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