Arrhythmias & electrophysiology
Catheter Ablation vs Antiarrhythmic Drug Therapy for Treatment of Premature Ventricular Complexes: A Systematic Review
Authors' conclusion
In conclusion, CA seems to reduce recurrence, burden, and frequency of PVCs compared with AADs.
Study context
- Population
- Patients with premature ventricular complexes (PVCs), mainly outflow tract PVCs5 studies (1 RCT)
- Participants
- 1,113 patients
- Comparison
- Catheter ablation vs antiarrhythmic drug therapy
- Outcome
- PVC recurrence, frequency and burden
Methodological detailsSignificant heterogeneity in AAD choice, Electroanatomic mapping used in 3 of 5 studies; no studies documented intracardiac echocardiography or contact force-sensing catheter use, Acute procedural endpoints varied (2 of 5 targeted elimination of all PVCs)
- Significant heterogeneity in AAD choice
- Electroanatomic mapping used in 3 of 5 studies; no studies documented intracardiac echocardiography or contact force-sensing catheter use
- Acute procedural endpoints varied (2 of 5 targeted elimination of all PVCs)
Pooled result
As reported in the abstract
- Catheter ablation (CA) seemed superior to AADs for PVC recurrence, frequency, and burden
- All studies had significant potential for bias
Further pooled results
Long-term symptoms
- One study reported long-term symptoms (CA superior)
Quality of life, cost-effectiveness
- Not reported
Safety
| Outcome | CA | AADs |
|---|---|---|
| Complication and adverse event ratesRange across studies | 0% to 5.6% | 9.5% to 21% |
Original publication
Catheter Ablation vs Antiarrhythmic Drug Therapy for Treatment of Premature Ventricular Complexes: A Systematic Review. JACC Clin Electrophysiol. Published 22 March 2023. doi:10.
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