Pulmonary vascular disease & thromboembolism
Catheter-directed mechanical aspiration thrombectomy in a real-world pulmonary embolism population: a multicenter registry
Authors' conclusion
These observational findings suggest that CDMT may improve hemodynamics with an acceptable safety profile in patients with IHR and HR PE.
Study context
- Population
- Patients with intermediate-high risk and high-risk pulmonary embolism (PE), 2019–202271.8% intermediate-high risk (IHR), 28.2% HR PE
- Participants
- 110 patients
- Outcome
- Safety: device or PE-related death within 48 h after CDMT, procedure-related major bleeding or other major adverse events; efficacy: reduction of PA pressures and change in RV/LV ratio
- Follow-up
- 24-48 h after CDMT (imaging)
Methodological detailsmulticenter
- Multicenter
Main finding
As reported in the abstract
Immediate haemodynamic changes
Drop in systolic PAP
10.4 ± 7.8 mmHg
19.7%P < 0.0001
Drop in mean PAP
6.1 ± 4.2 mmHg
18.8%
Drop in RV/LV ratio
0.48 ± 0.4
36%P < 0.0001
Observational data: associations, not effects.
Further findings
Deaths and procedural complications
- Intraprocedural death related to RV failure
- 0.9%
- Deaths within first 48 h
- 5.5%
- Major bleeding
- 1.8%
- Pulmonary artery injury
- 1.8%
- Ischaemic stroke
- 0.9%
Original publication
Catheter-directed mechanical aspiration thrombectomy in a real-world pulmonary embolism population: a multicenter registry. Eur Heart J Acute Cardiovasc Care. Published 15 June 2023. doi:10.
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