Heart failure & cardiomyopathies
Characteristics and Outcomes of Patients with Heart Failure and History of Malignancy: Data from Swedish Heart Failure Registry and the National Cancer Register
Main finding · All-cause mortalityResult — go to the resultAdjusted hazard ratio 1.14 95% CI 1.11–1.18Authors' conclusion
Previous cancer was common among patients with HF, and it was associated with comorbidity burden, non-cardiovascular outcomes and, in HFrEF, with lower use of guideline-recommended therapies.
Study context
- Population
- Patients with Heart Failure (HF) in the Swedish HF Registry, 2000–2020
- Participants
- 53,314 patients
- Exposure
- Previous cancer vs no previous cancer
- Previous cancern = 9,066
- Outcome
- All-cause mortality
- Follow-up
- Median 2.4 (0.0-5.0) years
Methodological detailsSwedish HF Registry linked with National Cancer Register
- Swedish HF Registry linked with National Cancer Register
Main finding
As reported in the abstract
Adjusted hazard ratio
1.14
95% CI 1.11–1.18
By group
Previous cancervs No cancer
adjusted HR 1.14 (95% CI 1.11–1.18)
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (95% CI) | |
|---|---|---|
| Non-CV death | 1.38 (1.31–1.44) | |
| First all-cause hospitalization | 1.11 (1.09–1.14) | |
| 0.512Adjusted hazard ratio (log scale) |
Deaths due to cancer
Non-CV death
- Risk of non-CV death declined with increasing time from cancer diagnosis
HF therapy use in HF and reduced ejection fraction (HFrEF)
- Previous cancer associated with less frequent use of MRA, triple pharmacotherapy and HF devices
Original publication
Characteristics and Outcomes of Patients with Heart Failure and History of Malignancy: Data from Swedish Heart Failure Registry and the National Cancer Register. Eur J Heart Fail. Published 17 July 2025. doi:10.
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